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RU

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2 549 953

(13)

C2

(51)

IPC

A61K31/409(2006-01-01)

A61P43/00(2006-01-01)

A61K35/00(2006-01-01)

(21) (22)

Application

2013157611/15, 2013-12-25

(24)

Start date

2013-12-25

(22)

Actual filing date

2013-12-25

(45)

Published

2015-05-10

(72)

Inventor

Makarova Elena AleksandrovnaJakubovskaja Raisa IvanovnaVorozhtsov Georgij NikolaevichLastovoj Anton PavlovichLuk'Janets Evgenij AntonovichMorozova Natal'Ja BorisovnaPlotnikova Ekaterina Aleksandrovna

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Gosudarstvennyj Nauchnyj Tsentr Institut Organicheskikh Poluproduktov I Krasitelej"Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauchno-Issledovatel'Skij Onkologicheskij Institut Im. P.A. Gertsena Ministerstva Zdravookhranenija Rossijskoj Federatsii Im. P.A. Gertsena" Minzdrava Rossii)

PHOTOSENSITISER FOR PHOTODYNAMIC THERAPY Russian patent published in 2015 - IPC A61K31/409 A61P43/00 A61K35/00 

Abstract RU 2549953 C2

FIELD: medicine.

SUBSTANCE: what is presented is using meso-tetra(3-pyridyl)bacteriochlorin of structural formula (I) as a near-infrared photosensitiser for a photodynamic therapy. Doses 1.0-2.5 mg/kg of the declared photosensitiser have provided 70-100% tumour growth inhibition, 80-131% increase in life expectancy and 25-100% animals' recovery by selective tumour collection and fast clearance.

EFFECT: high photoinduced activity on human tumour cells of various epithelial origin and high dose-dependent anti-tumour effectiveness in the animal with tumours of various origins.

5 dwg, 8 ex

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RU 2 549 953 C2

Authors

Makarova Elena Aleksandrovna

Jakubovskaja Raisa Ivanovna

Vorozhtsov Georgij Nikolaevich

Lastovoj Anton Pavlovich

Luk'Janets Evgenij Antonovich

Morozova Natal'Ja Borisovna

Plotnikova Ekaterina Aleksandrovna

Dates

2015-05-10—Published

2013-12-25—Filed

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