WATER-SOLUBLE DOSAGE FORM OF MESO-TETRA(3-PYRIDYLE)BACTERIOCHLORIN FOR PHOTODYNAMIC THERAPY Russian patent published in 2018 - IPC A61K31/409 A61P35/00 C07D487/22 

Abstract RU 2663900 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a water-soluble dosage form of a photosensitizer of the near-IR spectral region for photodynamic therapy of meso-tetra(3-pyridyl)bacteriochlorin (λmax = 747 nm) of the structural formula: , which is a lyophilizate for the preparation of a solution for infusions, containing a non-ionic surfactant kolliphor ELP, mannitol and citric acid at the next optimum content of auxiliary components per 1 mg of active ingredient: kolliphor ELP – 80 mg±10 %; D(-)-mannitol – 200 mg ± 10 %; citric acid – 0.5 mg ± 10 %.

EFFECT: water-soluble dosage form of meso-tetra(3-pyridyl)bacteriochlorin, stable under long-term storage, with high photoinduced activity was obtained.

1 cl, 6 dwg

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RU 2 663 900 C1

Authors

Lukyanets Evgenij Antonovich

Makarova Elena Aleksandrovna

Kalinichenko Alla Nikolaevna

Starkova Nataliya Nikolaevna

Bezulenko Valentina Nikolaevna

Kobzeva Elena Sergeevna

Yakubovskaya Raisa Ivanovna

Morozova Natalya Borisovna

Plotnikova Ekaterina Aleksandrovna

Plyutinskaya Anna Dmitrievna

Stramova Valentina Olegovna

Dates

2018-08-13Published

2017-08-21Filed