HIGH-AFFINITY HUMAN ANTI-PCSK9 ANTIBODIES Russian patent published in 2015 - IPC C07K16/40 C12N15/13 C12N15/63 A61K39/395 A61P3/06 

FIELD: medicine.

SUBSTANCE: presented invention refers to immunology. Disclosed are versions of a human antibody or an antigen-binding fragment of the human antibody, which specifically bind and inhibit human proprotein convertase subtilisin/kexin type 9 (hPCSK9). Each version is characterised by the fact that it contains 6 CDRs of heavy and light chains. Described are: an isolated coding nucleic acid, and expression vector and a method for producing the antibody with the use of the above vector. Presented is a pharmaceutical formulation based on the antibody for treating a disease or a condition which can be relieved, improved, suppressed or prevented by means of the anti-PCSK9 antibody.

EFFECT: using the invention provides the new versions of the antibodies able to reduce serum low-density lipoprotein cholesterol accompanied by no considerable changes or no effect on the hepatic function according to measured alanine-aminotransferase and aspartate-aminotransferase.

8 cl, 14 dwg, 28 tbl, 17 ex