HIGH AFFINITY HUMAN PCSK9 ANTIBODIES Russian patent published in 2019 - IPC C07K16/40

Abstract RU 2697773 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and represents a host cell for producing an isolated antibody or antigen-binding fragment thereof, which specifically binds PCSK9. Said host cell comprises a nucleic acid molecule encoding a heavy chain variable region (HCVR) region of the PCSK9 antibody comprising the amino acid sequence SEQ ID NO: 90, and a nucleic acid molecule encoding the light chain variable region of the anti-PCSK9 antibody comprising SEQ ID NO: 92. Invention also relates to a method for producing the anti-PCSK9 antibody, a pharmaceutical composition and use of the antibody.

EFFECT: invention widens the range of antibodies specifically binding PCSK9.

6 cl, 14 dwg, 28 tbl, 17 ex

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RU 2 697 773 C2

Authors

Sliman Mark U.

Martin Dzhoel Kh.

Khuan Tammi T.

Makdonald Duglas

Dates

2019-08-20—Published

2009-12-15—Filed