METHOD OF TREATING LOCALLY ADVANCED STOMACH CANCER WITH HIGH METABOLIC AND PROLIFERATIVE ACTIVITY Russian patent published in 2015 - IPC G01N33/48 A61K33/18 A61K31/4745 A61P35/00 

FIELD: medicine.

SUBSTANCE: CEA, CA 19-9, CA 72-4, M2-PK cancer-specific markers and Ki-67 proliferation index are pre-determined; combined positron emission and computer tomography (PET/CT) are performed. Up to two procedures of neoadjuvant intra-arterial chemoembolisation are conducted with the first one performed by administering a half single systemic dose of irinotecan in lipiodol 4-6 ml; no sooner than 2-3 weeks later, the cancer-specific markers and Ki-67 proliferation index and PET/CT SUVmax are checked; if at least one of this factors tends to increase as compared to references, the intra-arterial chemoembolisation is conducted again by administering at least 1/3 single systemic dose of irinotecan in no more than lipiodol 5 ml. Not later than 10-14 days following the second chemoembolisation or no sooner than 2-3 weeks after the first chemoembolisation, a surgical intervention is required if the tumour keeps its metabolic and proliferative activity on these days.

EFFECT: method enables decreasing the tumour process activity and performing the surgical intervention at the moment of extreme devitalisation of the tumour and micro-disseminates, and thereby improving the remote therapeutic effects.

2 cl, 4 dwg, 3 ex