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2 552 422

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IPC

C07D209/42(2006-01-01)

A61K31/404(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2013132982/04, 2013-07-17

(24)

Start date

2013-07-17

(22)

Actual filing date

2013-07-17

(45)

Published

2015-06-10

(72)

Inventor

Filimonova Marina VladimirovnaTsyshkova Nina GavrilovnaNarovljanskij Aleksandr NaumovichMarinchenko Valentina PavlovnaKoval' Lidija SemenovnaParfenova Tat'Jana MikhajlovnaIzmest'Eva Anastasija Vasil'EvnaErshov Feliks Ivanovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Radiologicheskij Nauchnyj Tsentr Ministerstva Zdravookhranenija Rossijskoj Federatsii Mrnts Minzdrava Rossii)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Ehpidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhranenija Rossijskoj Federatsii Im. N.F. Gamalei Minzdrava Rossii)

INDOLE-3-CARBOXYLIC ACID DERIVATIVES HAVING ANTIVIRAL ACTIVITY Russian patent published in 2015 - IPC C07D209/42 A61K31/404 A61P31/12

Abstract RU 2552422 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and particularly to aminoalkyl esters of 5-methoxyindole-3-carboxylic acid and pharmacologically acceptable salts thereof of general formula (I), where R1 is cyclohexyl, C_1-3alkyl; R2 is phenylthio, phenyloxy, wherein the phenyl group can have 1-2 halogen substitutes or a C_1-4alkoxy group, or R2 is a 5-6-member heterocycloalkyl containing 1-2 heteroatoms selected from nitrogen and oxygen; n equals 1, 2, 3, 4; each R is independently selected from C_1-4alkyl; except compounds indicated in the claim. The invention also relates to a method of producing a compound of formula (I) and use thereof.

EFFECT: obtaining novel 5-methoxyindole-3-carboxylic acid derivatives, having antiviral activity.

4 cl, 2 tbl, 12 ex

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RU 2 552 422 C2

Authors

Filimonova Marina Vladimirovna

Tsyshkova Nina Gavrilovna

Narovljanskij Aleksandr Naumovich

Marinchenko Valentina Pavlovna

Koval' Lidija Semenovna

Parfenova Tat'Jana Mikhajlovna

Izmest'Eva Anastasija Vasil'Evna

Ershov Feliks Ivanovich

Dates

2015-06-10—Published

2013-07-17—Filed