DERIVATIVE 4-AMINOMETHYL-6-BROMINE-5-HYDROXYINDOLE-3-CARBOXYLATE, METHODS OF THEIR OBTAINING (VERSIONS) AND THEIR APPLICATION Russian patent published in 2008 - IPC C07D209/42 C07D401/10 A61K31/404 A61P31/16 

FIELD: chemistry.

SUBSTANCE: invention relates to the new derivative 4-aminomethyl-5-hydroxyindole-3-carboxylate of the general formula I: where; R indicates cyclohexyl, cycloheptyl; R₁ indicates C₁-C₃-alkyl, -CH₂-X-phenyl; X indicates NH, O, S; R₂ indicates C₁-C₅-alkyl, R₃, R₄ have identical value and are selected from C₁-C₃-alkyl, predominantly, CH₃, or R₃ and R₄ together with a nitrogen atom form -5-10- member heterocycle, which contains 1-2- heteroatom selected from N, O, S or their pharmaceutically acceptable salts, with the exception of 6-bromine-5-hydroxy-4-dimethylaminomethyl-2-phenylthiomethyl-1-cyclohexyl-3-ethoxycarbonylindole, 6-bromine-5-hydroxy-4-dimethylaminomethyl-2-methyl-1-cyclohexyl-3-ethoxycarbonylindole, 6-bromine-5-hydroxy-4-dimethylaminomethyl-2-(piperidinomethyl)-1-cyclohexyl-3-ethoxycarbonylindole, 6-bromine-5-hydroxy-4-dimethylaminomethyl-2-(pirrolidinemethyl)-1-cyclohexyl-3-ethoxycarbonylindole and methyl-1-cyclohexyl-4-piperidinomethyl-6-bromine-5-hydroxy-2-methyl-indole-3-carboxylate. The methods of obtaining compound I are described.

EFFECT: exhibit antiviral activity and can be used for treating influenza of the type A.

5 cl, 2 dwg, 2 tbl, 8 ex