FIELD: pharmacology.
SUBSTANCE: during the trial rabbits are given the inhibitor preparation lynestrenol in vivo endogastrically with the daily dose of 110 mkg/kg of animal body weight in the course of 14, 21 or 28 days.
EFFECT: invention makes it possible to use lynestrenol as positive control of lower activity of glycoprotein-P for prediction of inclusion of studied medicinal agents into substrates of a transporter protein.
1 tbl
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Authors
Dates
2015-06-10—Published
2014-01-09—Filed