HYDROLYZATE OF TANSY FLOWERS COMPLEX POLYSACCHARIDE COMPLEX AS A GLYCOPROTEIN-P TRANSPORTER PROTEIN INHIBITOR Russian patent published in 2019 - IPC A61K36/28 A61K31/715 

Abstract RU 2699042 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, specifically to use of polysaccharide hydrolyzate tansy habitus as a transporter protein inhibitor glycoprotein-P. Application of hydrolyzate of polysaccharide complex of flowers tansy with a molecular weight of 3.8 kDa, produced method for acid hydrolysis of tansy flowers with 0.1 M sulfuric acid for 3 hours, as a transporter protein inhibitor glycoprotein-P.

EFFECT: obtained hydrolyzate in vitro tests inhibits activity Pgp, and by severity of effect it is comparable to classic inhibitor of transporter protein verapamil.

1 cl, 1 dwg, 1 tbl

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RU 2 699 042 C1

Authors

Yakusheva Elena Nikolaevna

Chernykh Ivan Vladimirovich

Esenina Anna Sergeevna

Shchulkin Aleksej Vladimirovich

Popova Natalya Mikhajlovna

Kirichenko Ekaterina Evgenevna

Grandinar Mariya Mikhajlovna

Dates

2019-09-03Published

2019-02-01Filed