METHOD FOR OBTAINING MODULATORS OF CYSTIC FIBROUSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Russian patent published in 2015 - IPC C07D215/56 C07D487/08 

Abstract RU 2553989 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a method of obtaining solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (compound 1 of form A, A-HCl, B and B-HCl). Methods of obtaining intermediate compounds 2 and 3-HCl are also described.

EFFECT: methods for obtaining compound 1 in the solid form, useful as CFTR modulators have been elaborated , .

21 cl, 22 dwg, 11 tbl, 8 ex

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RU 2 553 989 C2

Authors

Ambkhaikar Narendra Bkhalchandra

Kh'Juz Robert

Kharli Dennis Dzhejms

Li Ehlejn Chungmin

Littler Bendzhamin

Numa Mekhdi

Reper Shtefani

Shet Urvi

Dates

2015-06-20Published

2010-10-21Filed