FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a method of obtaining solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (compound 1 of form A, A-HCl, B and B-HCl). Methods of obtaining intermediate compounds 2 and 3-HCl are also described.
EFFECT: methods for obtaining compound 1 in the solid form, useful as CFTR modulators have been elaborated ,
.
21 cl, 22 dwg, 11 tbl, 8 ex
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Authors
Dates
2015-06-20—Published
2010-10-21—Filed