FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a method of obtaining solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (compound 1 of form A, A-HCl, B and B-HCl). Methods of obtaining intermediate compounds 2 and 3-HCl are also described.
EFFECT: methods for obtaining compound 1 in the solid form, useful as CFTR modulators have been elaborated , .
21 cl, 22 dwg, 11 tbl, 8 ex
Title | Year | Author | Number |
---|---|---|---|
SOLID FORMS OF N-(4-(7-AZABICYCLO[2,2,1]HEPTAN-7-YL)-2-(TRIFLUOROMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE | 2010 |
|
RU2568608C2 |
SOLID FORMS OF N-(7-AZABICYCLO[2,2,1]HEPTAN-7-YL-)-2-(TRIFLUOROMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYDROQUIINOLINE-3-CARBOXAMIDE | 2009 |
|
RU2518479C2 |
METHOD OF OBTAINING MODULATORS OF CYSTIC FIBROUSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | 2010 |
|
RU2543714C2 |
3-CARBOXAMIDE-4-OXOQUINOLINE DERIVATIVES, USEFUL AS MODULATORS OF REGULATOR OF TRANSMEMBRANE CYSTIC FIBROSIS CONDUCTIVITY | 2010 |
|
RU2518897C2 |
METHOD OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS | 2011 |
|
RU2745977C2 |
METHOD FOR PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS | 2011 |
|
RU2569678C2 |
SOLID FORMS OF 3-(2, 2-DIFLUOROBENZO[D][1,3] DIOXOL-5-YL)CYCLOPROPANCARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID | 2011 |
|
RU2579370C2 |
PHARMACEUTICAL COMPOSITIONS FOR TREATING DISEASES MEDIATED BY A TRANSMEMBRANE REGULATOR OF CYSTIC FIBROSIS (CFTR) | 2013 |
|
RU2692676C2 |
PHARMACEUTICAL COMPOSITIONS FOR TREATING DISEASES MEDIATED BY CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | 2015 |
|
RU2744460C2 |
METHOD OF PRODUCING PHARMACEUTICAL COMPOSITIONS FOR TREATING CFTR MEDIATED DISEASES | 2014 |
|
RU2718044C2 |
Authors
Dates
2015-06-20—Published
2010-10-21—Filed