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2 518 897

(13)

(51)

IPC

C07D215/233(2006-01-01)

A61K31/47(2006-01-01)

A61P1/18(2006-01-01)

A61P11/00(2006-01-01)

A61P27/00(2006-01-01)

(21) (22)

Application

2011142297/04, 2010-03-19

(24)

Start date

2010-03-19

(22)

Actual filing date

2010-03-19

(45)

Published

2014-06-10

(72)

Inventor

Jang SjaotsinAdida Rua Sara S.Grotenkhejs Peter D. J.Van Gor Fredrik FBotfild Martin K.Zlokarnik Gregor

(73)

Holder

Verteks Farmas'Jutikalz Inkorporejted

3-CARBOXAMIDE-4-OXOQUINOLINE DERIVATIVES, USEFUL AS MODULATORS OF REGULATOR OF TRANSMEMBRANE CYSTIC FIBROSIS CONDUCTIVITY Russian patent published in 2014 - IPC C07D215/233 A61K31/47 A61P1/18 A61P11/00 A61P27/00

Abstract RU 2518897 C2

FIELD: chemistry.

SUBSTANCE: invention relates to formula compound or to its pharmaceutically acceptable salt, where R represents COOH or CH₂OH. Invention also relates to pharmaceutical composition based on formula I, method of modulating CFTR activity in biological sample, based on application of formula I compound, method of treatment, based on application of formula I compound, set based on formula I compound.

EFFECT: obtained are novel derivatives of quinolin-4-one, useful as CFTR modulators.

18 cl, 1 tbl, 8 ex

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RU 2 518 897 C2

Authors

Jang Sjaotsin

Adida Rua Sara S.

Grotenkhejs Peter D. J.

Van Gor Fredrik F

Botfild Martin K.

Zlokarnik Gregor

Dates

2014-06-10—Published

2010-03-19—Filed