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2 745 977

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IPC

C07D209/40(2006-01-01)

(21) (22)

Application

2015145784, 2011-04-21

(24)

Start date

2011-04-21

(22)

Actual filing date

2011-04-21

(45)

Published

2021-04-05

(72)

Inventor

Tenouri Dzherald Dzh.Kharrison KristianLittler Bendzhamin DzhozefRouz Piter DzhejmisonKhyuz Robert MajklDzung Joung ChunSisel Devid EndryuLi Elejn ChungminBelmont Deniel T.

(73)

Holder

Verteks Farmasyutikalz Inkorporejted

METHOD OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS Russian patent published in 2021 - IPC C07D209/40

Abstract RU 2745977 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula III, where independently for each occurrence, R₂ is halogen; R₃ is C_1-6 aliphatic group substituted with OP; P is acetyl, benzoyl, benzyl, β-methoxyethoxymethyl ester, dimethoxytrityl, methoxymethyl ester, methoxytrityl, para-methoxybenzyl ether, pivaloyl, tetrahydropyranyl, trityl and trimethylsilyl; and o is 1.

EFFECT: obtaining a novel intermediate compound, which is applicable for producing (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, which in turn can be used in medicine for treating CFTR mediated diseases, such as cystic fibrosis.

3 cl, 6 tbl

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RU 2 745 977 C2

Authors

Tenouri Dzherald Dzh.

Kharrison Kristian

Littler Bendzhamin Dzhozef

Rouz Piter Dzhejmison

Khyuz Robert Majkl

Dzung Joung Chun

Sisel Devid Endryu

Li Elejn Chungmin

Belmont Deniel T.

Dates

2021-04-05—Published

2011-04-21—Filed