SOLID FORMS OF N-(4-(7-AZABICYCLO[2,2,1]HEPTAN-7-YL)-2-(TRIFLUOROMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE Russian patent published in 2015 - IPC C07D401/12 C07D487/08 A61K31/4709 A61P11/00

Abstract RU 2568608 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to novel solid forms of N-(4-(7-azabicyclo[2,2,1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (A-HCl forms, B forms, B-HCl forms). The invention also relates to pharmaceutical compositions based on A-HCl forms, or B forms, or B-HCl forms, or combinations thereof; a method of treating diseases caused by CFTR mutations; a method of modulating CFTR activity in a biological sample.

EFFECT: obtaining novel stable solid forms of N-(4-(7-azabicyclo[2,2,1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, having biological activity.

32 cl, 24 dwg, 13 tbl, 8 ex

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RU 2 568 608 C2

Authors

Chzhan Behjli

Kravets Mariush

Luizi Brajan

Medek Ales

Dates

2015-11-20—Published

2010-10-21—Filed