AROMATIC 6,7-DISUBSTITUTED 3-QUINOLINECARBOXAMIDE DERIVATIVES, METHOD FOR PRODUCTION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF IN DRUG MANUFACTURING Russian patent published in 2006 - IPC C07D215/54 C07D413/12 C07D401/12 C07D417/12 C07D413/14 C07D409/12 C07D491/56 A61K31/47 A61K31/4709 A61K31/4741 A61P37/00 A61P11/06 

Abstract RU 2281940 C2

FIELD: organic chemical, pharmaceuticals.

SUBSTANCE: invention relates to new compounds having JAK3 kinase inhibitor activity, methods for production thereof, intermediates, and pharmaceutical composition containing the same. In particular disclosed are aromatic 6,7-disubstituted 3-quinolinecarboxamide derivatives of formula I and pharmaceutically acceptable salts thereof useful in production of drugs for treatment of diseases mediated with JAK3. In formula n = 0 or 1; X represents NR3 or O; Ar is selected from phenyl, tetrahydronaphthenyl, indolyl, pyrasolyl, dihydroindenyl, 1-oxo-2,3-dihydroindenyl or indasolyl, wherein each residue may be substituted with one or more groups selected from halogen, hydroxy, cyano, C1-C8-alkoxy, CO2R8, CONR9R10 C1-C8-alkyl-O-C1-C8-alkyl, etc., wherein R-groups are independently hydrogen atom or C1-C8-alkyl; meanings of other substitutes are as define in description.

EFFECT: new compounds having value biological properties.

17 cl, 222 ex

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RU 2 281 940 C2

Authors

Larsson Joakim

She Peter

Dates

2006-08-20Published

2002-05-06Filed