METHOD FOR PREDICTION OF PLACENTAL INSUFFICIENCY IN SECOND TRIMESTER OF PREGNANCY Russian patent published in 2015 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention represents a method for the prediction of placental insufficiency in the second trimester of pregnancy by the enzyme immunoassay of pregnant women's blood, differing by the fact that a known ultrasound procedure is used to determine the foetus's gender; pregnant women's venous blood angiogenic factors and cytokines are measured; if observing an increase of IL-12 of more than 3.2 pg/ml, the epidermal growth factor of more than 310 pg/ml, a decrease of the placental growth factor of less than 40.0 pg/ml in the pregnant women carrying the male foetuses, and an increase of ET-1 of more than 0.42 pg/ml, IL-1β of more than 17.6 pg/ml, TNF-α of more than 6.5 pg/ml in the pregnant women carrying the female foetuses, the above pregnant women are predicted to develop placental insufficiency.

EFFECT: higher prediction accuracy of placental insufficiency in the second trimester of pregnancy taking into account the foetus's gender.

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