METHOD FOR PREDICTION OF DEVELOPING PLACENTAL INSUFFICIENCY Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to laboratory diagnostics and concerns a method for early prediction of developing placental insufficiency. The method involves: measuring early blood serum interleukin 6 (IL-6), interleukin 8 (IL-8), a soluble vascular cellular adhesion molecule (sVCAM), a vascular endothelial growth factor (VEGF) and big-endothelin. Then, a prognostic index (PI) is calculated by formula: PI=0.63697X₁-0.02367X₂+0.00235X₃-0.03931X₄-15.99295X₅-2.11547, wherein X₁ is the IL-6 concentration, pg/ml; X₂ is the IL-8 concentration, pg/ml; X₃ is the sVCAM concentration, ng/ml; X₄ is the VEGF concentration, pg/ml; X₅ is the big-endothelin concentration, fmol/ml. If PI>0, developing placental insufficiency is predicted in the second half of pregnancy, while PI<0 enables stating a low risk of developing pathology specified above. The presented method is low-invasive, enables early detecting a risk group of developing placental insufficiency that makes it possible to take measures aiming at preventing the formation of the given pathology. Sensitivity of the method makes 77.4%, its specificity makes - 85.6%.

EFFECT: effectiveness of the method is 81,5%.

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