PHARMACEUTICAL COMPOSITION, CONTAINING INDOLE COMPOUND Russian patent published in 2015 - IPC C07D209/40 C07D235/18 A61K31/404 A61K31/4184 A61P1/16 A61P9/00 A61P19/02 A61P25/00 A61P29/00 A61P31/00 A61K8/49 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical composition, containing compound of formula or for prevention or treatment of diseases, associated with oxidative stress, selected from group, consisting of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke episodes), MERRF syndrome (myoclonic epilepsy with ragged red fibres) or Kearns-Sayre syndrome, arrhythmia, cardioplegia or myocardium infarction. in formula (1) na stands for 1 or 2, A^a represents 5-membered heteroaryl or heterocycle, each of which has 2 heteroatoms, selected from N, O and S, R^la represents R^5a-X^a-B^a-X′^a-, B^a represents direct bond, X^a and X′^a independently on each other represent direct bond or -OC(O)-, R^5a represents hydrogen or 6-9-membered monocyclic or condensed cyclic heterocycle or heteroaryl, each of which has from 1 to 3 heteroatoms, selected from N, O and S, and is optionally substituted with oxo or C₁-C₆-alkyl, R^2a represents -(CR^8aR^9a)_pa-Y^a-R^7a _, pa stands for number from 0 or 1, Y^a represents direct bond or -O-, R^7a represents hydrogen or phenyl, R^3a, R^8a, R^9a, R^10a represent hydrogen, R^4a represents -(CH₂)_pa-D^a-R^10a-, D^a represents C₅-cycloalkyl or 6-membered heterocycle, which has 1 heteroatom, selected from N, S and O. Radical values for formula (2) are give in invention formula.

EFFECT: obtaining compositions for prevention or treatment of diseases, associated with oxidative stress.

19 dwg, 5 tbl, 3 ex