FIELD: medicine.
SUBSTANCE: invention relates to field of biochemistry, in particular to method of identifying changes in gene expression, characteristic of ageing, in selected tissue. Selected tissue represents cardiac, muscular, cerebral or adipose tissue. Method includes selection of one or several genes, differentially expressed in tissue of old subjects in comparison with young subjects, with application of two criteria. Said criteria are: change of expression in at least 50% of lines, breeds or ethnic groups of tested species at preliminarily determined significance level p<0.10, as well as at least partial reversion of changes in gene expression by restriction in caloric content.
EFFECT: invention provides obtaining reliable tissue-specific biomarkers of ageing.
7 cl, 11 tbl, 5 ex
| Title |
Year |
Author |
Number |
| CARDIAC AGING BIOMARKER AND METHODS FOR USING THEM |
2010 |
|
RU2562174C2 |
| CONSTRUCTED CELLS, EXPRESSING MULTIPLE IMMUNOMODULATORS, AND THEREOF APPLICATION |
2009 |
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- Rid Tomas D.
|
RU2573912C2 |
| PROFILES OF EXPRESSION OF GENES ASSOCIATED WITH LEAN PHENOTYPE |
2009 |
- Pan Juan'Lun
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|
RU2532837C2 |
| COMPOSITIONS AND METHODS FOR DIAGNOSING AND MONITORING HYPERTHYROIDISM IN FELINES |
2012 |
- Al-Murrani Samer
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|
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| METHODS OF TREATING, DIAGNOSING AND MONITORING OF RHEUMATOID ARTHRITIS |
2010 |
- Dennis Ml. Glinn
- Martin Flavius
- Taunsend Majkl Dzh.
|
RU2539112C2 |
| APPLICATION OF ANTIOXIDANTS FOR GENE MODULATION |
2005 |
- Ziker Stiven Kertis
- Pehto-Robinson Inke
- Videkajnd Karen Dzhoj
|
RU2433819C2 |
| FODDER PRODUCT AND METHOD FOR TREATMENT OF DISORDERS ASSOCIATED WITH ANIMAL OVERWEIGHT |
2009 |
- Jamka Rajan Majkl
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- Al' Murrani Samer
|
RU2520853C2 |
| DIAGNOSTIC TECHNIQUE AND KIT FOR DIAGNOSING GLOMERULONEPHITIS IN CAT |
2011 |
- Al'-Murrani Samer Valid
- Gao Sjanmin
- Malladi Sukkhasvami
|
RU2564122C2 |
| METHODS AND COMPOSITIONS FOR TREATING DISEASE |
2007 |
- Rid Tomas D.
- Bich Robert P.
|
RU2468820C2 |
| RECOMBINANT ADEN-ASSOCIATED VIRUS, WHICH IS HYBRID OF AAV9 AND AAVrh74 SEROTYPES, WITH REDUCED TROPISM FOR LIVER TISSUE |
2019 |
- Rishar, Izabel
- Zhikkel, Evelin
- Mingotstsi, Federiko
- Rontsitti, Dzhuzeppe
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|
RU2812279C2 |
