FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, particularly to a method of diagnosing existence or risk of hyperthyroidism in a feline and a kit therefor. Method comprises measuring level of expression of one or more biomarkers in a biological sample from said animal with help of apparatus for measuring expression, such as antibody, aptamer or oligonucleotide probe. High expression IYD, CHI3L1, PDZK1IP1, MAPK13, PGD, MBOAT7, CTSD, CYP4F3, TGFB1, C20orf3, ACAA2, HTATIP2, RHOC, G6PD, GSTP1, CAPG, AP1S1, ATP6V1D, CAPN1, LASS4, PDCL, HSD3B7, LRPAP1, PARP3, ATP6AP1, B3GNT8, SORT1, TG, SLC5A5 (NIS), TPO, TSHR and DUOX2 (ThOX) and/or low expression C13orf27, GP1BB, IGLL1, LRRC4B, MALT1, REV3L, GNL3, RNPC3, LMO4, RFXAP, MPP6, DTWD1, MYC, TCEA3, RPAP2, ZNF292, CSGALNACT1, ZFP37, IGJ, LTBP1, ABCA5, GPRASP2, ARMCX1, SEPP1, DCN in sample relative to reference values of expression and/or relative to previous individual initial value for this animal indicates existence or high risk of hyperthyroidism.
EFFECT: invention widens range of products for diagnosing hyperthyroidism in cats.
19 cl, 3 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING HYPERTHYROIDISM OF COMPANION ANIMALS | 2012 |
|
RU2612901C2 |
| DIAGNOSTIC TECHNIQUE AND KIT FOR DIAGNOSING GLOMERULONEPHITIS IN CAT | 2011 |
|
RU2564122C2 |
| COMPOSITIONS, DIAGNOSTIC TECHNIQUES AND METHOD OF TREATING RENAL DISORDERS IN DOGS | 2010 |
|
RU2546016C2 |
| COMPOSITIONS AND METHODS FOR TREATMENT OF OSTEOARTHRITIS | 2009 |
|
RU2619553C2 |
| METHODS AND COMPOSITIONS FOR DIAGNOSTICS OF OSTEOARTHRITIS AT CAT FAMILY | 2008 |
|
RU2504586C2 |
| TISSUE-SPECIFIC BIOMARKERS OF AGEING | 2010 |
|
RU2557313C2 |
| MARKERS FOR ENDOMETRIAL CANCER | 2010 |
|
RU2596394C2 |
| CARDIAC AGING BIOMARKER AND METHODS FOR USING THEM | 2010 |
|
RU2562174C2 |
| MARKERS ASSOCIATED WITH WNT INHIBITORS | 2014 |
|
RU2663701C2 |
| METHODS FOR CLASSIFYING PATIENTS WITH SOLID CANCER | 2017 |
|
RU2745730C2 |
