1,4-DISUBSTITUTED IMIDAZOLE DERIVATIVE Russian patent published in 2021 - IPC C07D401/12 C07D403/12 C07D413/12 C07D417/12 A61K31/422 A61K31/427 A61K31/4439 A61K31/4709 A61P35/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention refers to 1,4-disubstituted imidazole derivatives used as a drug. Disclosed is compound of formula (1a'), where ring Q¹ is a phenyl, pyridyl or cyclohexyl group; R¹ and R² represent independently a hydrogen atom, a halogen atom or a C_1-6 alkyl group; W^1a and W^3a are an optionally substituted C_1-4 alkylene group; W² is a methylene group; W^2a-Q^2a is -NR^3aC(O)-Q^2a, -NR^3aC(O)CH₂O-Q^2a, -C(O)NR^3a-Q^2a or -NR^3aC(O)-CH=CH-Q^2a, where R^3a represents a hydrogen atom or a C_1-6 alkyl group; ring Q² is a pyridyl, pyrimidyl, pyridazinyl, pyrazyl, oxazolyl, thiazolyl, isoxazolyl or isothiazolyl group; m is 1, 2, 3, 4 or 5; R¹¹ is independently a hydrogen atom, a halogen atom, an optionally substituted C_1-6 alkyl group or C_1-6 alkoxy group; R¹² and R¹³ are independently a hydrogen atom, a halogen atom, C_1-6 alkyl group, C_1-6 alkoxy group, C_3-10 cycloalkyl group, C_2-6 alkenyl group, C_2-6 alkynyl group, cyano or amino group; R¹⁴ is a hydroxyl group or C_1-6 alkoxy group; and a pharmacologically acceptable salt thereof. Invention also discloses a medicinal preparation for treating cancer, an antitumour agent, a pharmaceutical composition containing said compound, method of treating cancer using said compound and versions of using the disclosed compound for preparing an agent for treating cancer.

EFFECT: technical result is disclosed compound has powerful inhibiting action on ability of cancer cells to spherogenesis and can be used as an orally administered antitumour agent.

29 cl, 85 ex