FIELD: pharmaceutics.
SUBSTANCE: present invention relates to a compound of the general formula (I) or its pharmaceutically acceptable salt, where Q is O, X1 and X3 are CH, X2 is CR1 or N, Y is CH or N, Z is CR2b or N, R1 is a hydrogen atom, a halogen atom or C1-C6 alkyl group, values of R2a and R2b are specified in cl. 1, or each of R2a and R2b is a group represented by the formula (I-A), where L is a single bond, -(CH2)p-, -O(CH2)p-, -(CH2)pO-, -(CH2)pO(CH2)q-, -NRc(CH2)p- or -(CH2)pNRc, where each of two hydrogen atoms (CH2)p and (CH2)q is optionally substituted with a halogen atom, p is 1 or 2, q is 1 or 2, Rc is a hydrogen atom or a methyl group, and ring B is phenyl, imidazolyl, triazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, pyridyl or pyrimidinyl, respectively, optionally substituted with C1-C4 alkyl group, provided that R2a and R2b are not simultaneously hydrogen atoms or, when Z is CR2b, R2a and R2b can form -(CH2)r-, where r is 3, 4 or 5, optionally substituted with a halogen atom, a hydroxyl group or an oxo group, and R3 is a hydrogen atom, a halogen atom, C1-C6 alkyl group or C1-C6 halogenalkyl group, ring A is selected from a group consisting of formulas specified in cl. 1, values of n, R4, R5a, R5b, R5c, X4, R6a and R6b are also specified in cl. 1, or compounds (I-227). The invention also relates to a drug and antifungal agent, a therapeutic agent based on the compound of the formula (I), the use of the compound of the formula (I) or drugs and agents based on it, as well as to a method for preventing or treating fungal infections, superficial mycosis or dermatophytic mycosis.
EFFECT: new heterocyclic compounds with excellent antifungal activity are obtained.
, 
, 
20 cl, 80 tbl, 439 ex
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