METHOD OF OBTAINING SUBSTITUTED QUINOLINES FROM ANILINE, 1,3-DIOLS AND CCl4 UNDER ACTION OF IRON-CONTAINING CATALYSTS Russian patent published in 2015 - IPC C07D215/04 C07D215/20 

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining substituted quinolines of formula

57-96%, where R¹ and R² = H; R¹ = CH₃, R² = H; R¹ = H, R² = CH₃; X = H, o-CH₃, m-CH₃, p-CH₃, o-C₂H₅, o-Cl, m-Cl, p-Cl, p-OMe, o-OH, by interaction of anilines with 1,3-diols under action of catalysts, characterised by the fact that substituted anilines of formula XC₆H₄NH₂, where X is as given above, is subjected to interaction with 1,3-diols (1,3-propanediol or 1,3-butanediol) and CCl₄ in presence of catalyst, selected from the group FeCl₃·6H₂O, FeCl₃, FeCl₂·4H₂O, Fe(C₅H₅)₂, Fe(acac)₃, Fe(OAc)₂ and Fe₂(CO)₉, with molar ratio [catalyst]:[aniline]:[CCl₄]:[diol]=1:100:200:400, at 150°C for 8 h, obtained reaction mass is neutralized, organic layer is extracted with CH₂Cl₂, filtered and solvent is distilled.

EFFECT: novel method of obtaining substituted quinolines, characterised by cheapening of final product production cost due to application of available initial reagents, has been elaborated.

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