METHOD FOR OBTAINING ALKYL ESTERS OF HYDROXYBENZOIC ACIDS Russian patent published in 2018 - IPC C07C69/88 C07C67/00 B01J31/16 B01J31/20 B01J31/22 B01J31/30 B01J23/745 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, in particular to a process for the preparation of alkyl esters of ortho- and para-hydroxybenzoic acids, which are used as starting compounds for the preparation of medicaments. Method comprises reacting phenol with carbon tetrachloride and alcohols (MeOH, EtOH, PrⁿOH, BuⁿOH) in the presence of a catalyst selected from FeBr₃, FeCl₃*6H₂O, Fe₂(CO)₉, FeCl₂, FeCl₃, Fe(acac)_3, FeCl₂*4H₂O, at a molar ratio of [Fe] : [phenol] : [CCl₄] : [ROH] = 1–10:100:300–1000:300–1000, at a temperature of 130 °C for 4–8 hours in an argon atmosphere. Following ratios of the catalyst and reactants are optimal for the reaction: [Fe₂(CO)₉]:[phenol]:[CCl₄]:[ROH]=5:100:500:500, at a temperature of 130 °C for 6 hours. Under these conditions, the output of methyl esters of ortho- and para-hydroxybenzoic acids is 18 % and 20 %, respectively, ethyl – 28 % and 45 %, propyl – 34 % and 66 % and butyl 38 and 62 % respectively.

EFFECT: method of producing alkyl esters of ortho- and para-hydroxybenzoic acids is proposed.

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