FIELD: medicine.
SUBSTANCE: invention refers to biotechnology. Disclosed are methods and compositions for the cancer detection in an individual and the treatment efficacy assessment in the same individual. What is disclosed is a method for using a polymerase chain reaction with reverse transcription (RT-PCR) and a multiplex chain reaction, as well as a template exchange and extension reaction for detecting point mutations, truncation and fusion of anaplastic lymphoma kinase.
EFFECT: presented group of inventions can be used in medicine.
24 cl, 6 dwg, 3 tbl, 5 ex
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