FIELD: chemistry.
SUBSTANCE: in order to obtain 2-(N,N-dialkylaminomethyl)styrenes containing a heterocyclic fragment of general formula 
, where R=CH2OCH2, R=o-C6H4, R=(CH2)3 or R=(CH2)2, isoquinoline is reduced to 1,2,3,4-tetrahydroisoquinoline in the presence of formic acid, triethylamine and (Ph3P)3RuCl2. The obtained 1,2,3,4-tetrahydroisoquinoline is converted to the end product in isopropanol solution under the effect of a corresponding dihalide and alkali.
EFFECT: invention provides milder conditions of the process of producing 2-amiomethyl styrenes containing a heterocyclic fragment, which do not require sophisticated equipment, an inert atmosphere, expensive and toxic reagents, with high output on the initial isoquinoline.
3 cl, 4 ex
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Number |
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|
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