METHOD OF PRODUCING 2-AMINOMETHYL STYRENES CONTAINING HETEROCYCLIC FRAGMENT Russian patent published in 2016 - IPC C07D295/03 C07D217/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 2-(N,N-dialkylaminomethyl)styrenes containing a heterocyclic fragment of general formula: where R=CH₂NHCH₂, R=o-CH₂C₆H₄ or R=(CH₂)₄, in which isoquinoline is reduced to 1,2,3,4-tetrahydroisoquinoline in presence of formic acid, triethylamine and tris-triphenylphosphinoruthenium dichloride. Then it is dissolved in ethanol solution under action of dihalide and alkali, mixture is evaporated, methyltertbutyl ether is added and stirred for 30-40 minutes. Obtained mixture is filtered through aluminium oxide powder to produce end product.

EFFECT: invention simplifies process and improves manufacturability owing to implementation thereof in mild conditions, which do not require complex equipment, an inert atmosphere, expensive and toxic reagents; also, higher yield of end products to 79-84 wt% of initial isoquinoline.

3 cl, 3 ex