METHOD FOR OBTAINING 2-(N,N-DIALKYLAMINOMETHYL)STYRENES, CONTAINING HETEROCYCLIC FRAGMENT Russian patent published in 2016 - IPC C07D295/03 C07D207/04 C07D209/44 C07D211/06 

FIELD: chemistry.

SUBSTANCE: invention relates to method for obtaining 2-(N,N-dialkylaminomethyl)styrenes, which contain heterocyclic fragment of general formula : wherein R = CH₂OCH₂, R = o-C₆H₄, R = (CH₂)₃ or R = (CH₂)₂. Method is performed in the following way: isoquinoline is reduced to 1,2,3,4-tetrahydroisoquinoline in presence of formic acid, triethylamine and dichloro(3-phenyl-1H-inden-1-yledene)bis(tricyclohexylphosphine)ruthenium. Obtained 1,2,3,4-tetrahydroisoquinoline is transferred into target product in monoreactor way without solvent under action of respective dihalogenide and alkali. Dihalogenide is selected from 2,2'-dichloroethyl ether, α,α-dichloro-o-xylene, 1,4-dibromobutane or 1,5-dibromopentane, with selection of alkali from sodium hydroxide or potassium hydroxide.

EFFECT: improvement of technological process of obtaining 2-aminomethylstyrenes, containing heterocyclic fragment, carried out under mild conditions, not requiring complex equipment, inert atmosphere, expensive and toxic reagents, with high output by initial isoquinoline.

3 cl, 4 ex