FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of biotechnology, genetic engineering and virology. Recombinant retrovirus vector codes inhibitor of HIV coreceptor, such as CCR5 or CXCR4, and protein, inhibiting fusion of HIV with target-cell or HIV replication. Pharmaceutical compositions, containing such constructions, and methods of thereof application for prevention or treatment of HIV infection in patients are also described. Claimed group of inventions can be used in medicine.
EFFECT: described is expression vector for prevention or suppression of HIV penetration, fusion or replication in mammalian cells.
57 cl, 24 dwg, 9 tbl, 11 ex
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