METHOD OF PREDICTING ACHIEVEMENT OF COMPLETE MORPHOLOGICAL REGRESSIONS IN PATIENTS WITH TRIPLE-NEGATIVE BREAST CANCER, WHO OBTAINED CHEMOTHERAPY COURSES IN CAX REGIMEN Russian patent published in 2015 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: immunohistochemical analysis of the tumour tissue is carried out. The level of expression is estimated for the obtained parameters. The value of regression equation is calculated by formula: Y=(5.38-16.2X₁-11.2X₂+5.98X₃+12.4X₄-5.39X₅), where X₁ is the condition of the regional lymphatic apparatus (0 - absence of the metastatic affection of lymph nodes, 1 - affection of up to 4 lymph nodes, 2 - affection of 4-9 lymph nodes, 3 - affection of 10 and more lymph nodes); X₂ is the level of EGFR1 expression ( 1 - lower than 10%, 2 - 10% and higher); X₃ is the level of thymidylate phosphorylase expression in the tumour cell cytoplasm (1 - lower than 20%, 2 - 20% and higher); X₄ is the level of Ki-67 expression (1 - lower than 20%, 2 - 20% and higher); X₅ is the level of VEGFR-2 expression (1 - lower than 70%, 2 - 70% and higher). The value of the probability of achieving CMR - P is calculated by formula: P=e^Y/(1+e^Y), where e is the mathematical constant, equal 2.72, and if P<0.5, a low and if P>0.5, a high probability of achieving CMR in CAX-treated patients is predicted.

EFFECT: method of prediction makes it possible to predict the achievement of CMP regressions in the patients with TNC, treated in the CAX regimen.

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