METHOD FOR PREDICTION OF LYMPHATIC CANCER SPREAD ACCOMPANIED BY INVASIVE NONSPECIFIC TRIPLE-NEGATIVE BREAST CANCER Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: molecular-genetic type of breast cancer is determined by the immune histochemical study of primary tumour tissue specimens; the patients' menstrual function state and morphological signs are also taken into consideration, and a regression equation Y is calculated by formula: Y=(11+32X₁-69.2X₂+1.04X₃-3.5X₄), wherein Y is the regression equation; (11) is an intercept ratio; X₁ is the patients' menstrual function state (1 - preserved; 2 - menopause); (32) is a regression ratio of this parameter; X₂ is tubular structures in the tumour infiltrate (1 - not found; 2 - found); (-69.2) is a regression ratio of this parameter; X₃ is the number of different types of structures in the tumour infiltrate (1 - one, 2 - two, 3 - three, 4 - four, 5 - five; (1.04) is a regression ratio of this parameter; X₄ is an intensity of the stroma inflammatory infiltration (1 - mild, 2 - moderate, 3 - pronounced; (-3.5) is a regression ratio of this parameter. A probability P is determined by formula: P=e^Y/(1+e^Y), wherein e is a mathematical constant equal to 2.72; if P≥50%, a high risk of the lymphatic cancer spread is stated, whereas P<50% shows a low risk thereof.

EFFECT: method enables increasing the prediction accuracy of the lymphatic cancer spread, and improving a therapeutic approach in due time.

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