FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing N-(3,3-dimethyl-3,4-dihydroisoquinolyl-1)-6-aminocaproic acid, which includes reacting 1-methylthio-3,3-dimethyl-3,4-dihydroisoquinoline with ε-aminocaproic acid while heating in an autoclave without a solvent, followed by purification of the product by crystallisation from water.
EFFECT: method significantly increases the output of the end product, cuts the duration of the process, reduces the risk of fire and material costs owing to use of water for recrystallisation.
2 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OBTAINING 1-SUBSTITUTED 3,3,4,4-TETRAMETHYL-3,4-DIHYDROISOHALINES | 2006 |
|
RU2326114C1 |
| ANALGETIC AGENT | 2001 |
|
RU2223763C2 |
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|
RU2213735C2 |
| METHOD OF PRODUCING 3-METHYL-6,7-DIALKOXY-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDES BASED ON EUGENOL | 2011 |
|
RU2524345C2 |
| (1Z,3Z)-4-HYDROXY-1-(3-BUTYL-3-METHYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE)-4-(4-TOLYL)BUT-3-EN-2-ONE EXHIBITING ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY | 2009 |
|
RU2402534C1 |
| (2Z,5Z-1-ARYL-3-HYDROXY-5-(3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2N)-YLIDENE)-PENT-2-ENE-1,4-DIONES AND METHOD OF PRODUCING SAID COMPOUNDS | 2008 |
|
RU2374232C1 |
| (1Z,3Z)-4-ARYL-4-HYDROXY-1-(3,3-DIALKYL-3,4-DIHYDROISOQUINOLIN-1(2N)-YLIDENE)-BUT-3-EN-4-ONES AND METHOD OF PRODUCING SAID COMPOUNDS | 2008 |
|
RU2374231C1 |
| (1Z, 3Z)-4-ARYL-4-HYDROXY-1-(3,3-DIALKYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE)BUT-3-EN-4-ONES AND SYNTHESIS METHOD THEREOF | 2009 |
|
RU2417221C1 |
| METHOD OF PREPARING N-P-R-BENZOYLPYRUVOIL-3,3-DIMETHYL-3,4-DIHYDRO DELTA-1(2H)-METHYLPYRAZOLE | 0 |
|
SU833961A1 |
| 0 |
|
SU444365A1 |
