FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to the field of biotechnology, namely to novel peptides, obtained from poison of the scorpion Rhopalurus junceus, and can be used in medicine. The peptide RjLB-014 is characterised by the molecular weight of 5930.45 Da and an amino acid sequence SEQ ID NO: 8. The obtained peptide can be used as a component of a pharmaceutical composition, mixed with distilled water as a filling agent, with the said components being present in the following concentration: RjLB-014 0.4-0.8%, distilled water 10-20 ml.
EFFECT: invention makes it possible to obtain the peptide from scorpion poison, possessing an increased cytotoxic activity with respect to tumour cells.
4 cl, 9 dwg, 23 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| USE OF SESQUITERPENE LACTONE COMPOUND IN PREPARING DRUGS FOR RELIEVING RADIATION-INDUCED INJURIES | 2021 |
|
RU2822760C1 |
| INHIBITORS OF CELL CYCLE CHECKPOINT KINASE 1 FOR AMPLIFICATION OF DNA-DAMAGING AGENTS | 2010 |
|
RU2567044C2 |
| ANTICANCER PHARMACEUTICAL COMPOSITION (VERSIONS) AND APPLICATION THEREOF | 2005 |
|
RU2396274C2 |
| RECOMBINANT IMMUNOTOXIN AIMED AT MESOTHELIN | 2012 |
|
RU2600067C2 |
| NONAPEPTIDE WITH ANTITUMOUR ACTIVITY | 2009 |
|
RU2503685C2 |
| PHARMACOLOGICAL COMBINATION OF POLYCATIONIC CARRIER PEG-PEI-TAT WITH INCLUDED IN IT PLASMID CARRYING THERAPEUTIC GENES HSVtk AND GM-CSF FOR GENE THERAPY OF TUMOROUS DISEASES | 2013 |
|
RU2575077C2 |
| COMBINATION THERAPY WITH ANTICANCER ALKALOID | 2018 |
|
RU2767664C2 |
| COMBINATION THERAPY WITH ANTITUMOR ALKALOID | 2011 |
|
RU2743643C2 |
| COMBINATION THERAPY WITH ANTITUMOR ALKALOID | 2018 |
|
RU2757373C2 |
| IMMUNOSTIMULATING POLYPEPTIDE DERIVATIVES OF TAT HIV FOR USE IN TREATING CANCER | 2014 |
|
RU2695653C2 |
