FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, specifically to compositions able to inhibit the growth of tumour cells of various histological origins and activated endothelial cells, and can be used in medicine. Components of the specified compositions are non-proteolytic polypeptide fragments of serralysines chosen from ARA1, ARA2, ARA3 and ARA4. Specified fragments of serralysines are also combined with prodigiosins and with antibodies or their antigen-binding fragments directed on antigens of tumour cells that intensify the anticancer effect of the composition.
EFFECT: invention allows preparing the composition with higher antiproliferative activity, in comparison with a composition containing the whole molecules of serralysines.
8 cl, 16 dwg, 7 tbl, 21 ex
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