FIELD: chemistry.
SUBSTANCE: present invention relates to a novel crystalline form of 4'-epidaunorubicine hydrochloride, process for the production thereof and use for the production of anthracyclines. The proposed form of crystalline 4'-epidaunorubicin hydrochloride is stable and readily soluble, with the powder X-ray diffraction pattern as follows (diffraction angle 2θ): 5,13, 7,64, 12,18, 16,77, 19,86, 21,82, 22,58, 23,03.
EFFECT: advantageous process for producing crystalline form by comprising crystallising 4′-epidaunorubicin hydrochloride in a solvent system including C1 and C2 halogenated solvents, C1-C5 alcohols, wherein one of C1-C5 alcohols is selected to provide lower solubility to 4′-epidaunorubicin hydrochloride than the other C1-C5 alcohol.
18 cl, 2 dwg, 4 tbl, 7 ex
