FIELD: technological processes.
SUBSTANCE: present invention relates to a method for purifying epidaunorubicin, which can be used in biotechnology. Such proposed method includes the following steps: a) providing a mixture comprising epidaunorubicin, epifeudomycin, and at least one halogenated solvent; b) adjusting the pH of the mixture in the range of 5.0 to 7.5; c) heating the mixture in step b) to the temperature greater than 25 °C; and d) purification of epidaunorubicin, and is characterized in that the content of alcohols with 1 to 5 carbon atoms in the mixture in steps a) and b) is no more than 5 vol., based on the total volume of the mixture.
EFFECT: new effective method for removing epifeudomycin from epidaunorubicin, the former is formed as a by-product in the biotechnological production of epidaunorubicin, is proposed.
12 cl, 1 ex, 3 tbl
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| CRYSTALLISATION OF 4′-EPIDAUNORUBICINE X HCI | 2010 |
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| METHOD FOR PURIFYING FERMENTATION BROTH | 2001 |
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| ISOLATION OF CAROTINOID CRYSTALS | 2001 |
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| ADJUVANT COMPOSITION CONTAINING 3-O-DEACYLATED 4′-MONOPHOSPHORYL LIPID A | 2006 |
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| METHODS OF PROCESSING LIGNOCELLULOSIC MATERIALS | 2013 |
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| PROCESS FOR PREPARATION OF IOPAMIDOL | 2014 |
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RU2657238C2 |
| POLYSACCHARIDE FROM ECHINACEA ANGUSTIFOLIA ROOTS, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION | 2003 |
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