FIELD: pharmaceutics.
SUBSTANCE: invention relates to a method of producing crystalline epirubicin chloride which is valuable in pharmaceutical industry. Disclosed method comprises: (a) obtaining epirubicin hydrochloride, (b) preparing a mixture which contains obtained epirubicin hydrochloride and at least one alcohol selected from a group consisting of 1-butanol, 2-butanol and 1-pentanol, and (c) crystallisation of hydrochloride epirubicin from said mixture, mixture at step (b) additionally contains water and fraction of epirubicin hydrochloride ranges from 10 to 50 g/l in relation to volume of mixture, and mixture is held at 50-75 °C for at least two hours.
EFFECT: novel efficient method of producing thermally stable crystalline epirubicin.
14 cl, 4 ex, 2 dwg
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