BICYCLIC DERIVATIVES OF GUANIDINE AND THEIR THERAPEUTIC USING Russian patent published in 2006 - IPC C07D277/64 C07D235/14 C07D333/58 C07D209/14 C07D307/81 C07C279/08 A61K31/343 A61K31/381 A61K31/404 A61K31/4184 A61K31/155 A61K31/428

Abstract RU 2282622 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to compounds of the general formula (I): wherein A means benzene ring optionally substituted with one or more the following groups: -OR2 wherein R2 mean linear or branched (C₁-C₅)-alkyl; X means -CH=, -CH₂-, -N= or -NH-radical; Y means radical -CH₂, oxygen or sulfur atom or group -NR7 wherein R7 means hydrogen atom or linear or branched (C₁-C₅)-alkyl; R1 means hydrogen atom, linear or branched (C₁-C₅)-alkyl, and to pharmaceutically acceptable salts also. Also, invention relates to a pharmaceutical composition showing anti-diabetic activity. The pharmaceutical composition comprises compound of the general formula (I) as an active component and an inert excipient. Invention provides bicyclic derivatives of guanidine eliciting anti-diabetic activity.

EFFECT: valuable medicinal properties of compounds and composition.

8 cl, 2 tbl, 4 ex

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RU 2 282 622 C2

Authors

Muane Zherar

Kravo Dan'El'

Dates

2006-08-27—Published

2002-02-27—Filed