BENZAMIDE DERIVATIVES HAVING ANTICANCER ACTIVITY, METHODS FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2015 - IPC C07C233/65 C07C233/92 C07C231/02 C07C231/12 C07C271/64 C07C269/04 C07C255/57 C07C253/30 A61K31/166 A61K31/27 A61K31/277 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, where R¹ and R² are independently selected from a group consisting of hydrogen, unsubstituted (C₁-C₈)alkyl, -COR⁵ and -CO₂R⁶; R¹ and R² can also be cyclised to form a substituted or unsubstituted 4-, 5- or 6-member ring, selected from morpholine, piperidine, pyrrolidine, piperazine, azetidine, 4-methylpiperazine; R³ is nitro or nitroso; R⁴ is selected from a group consisting of ethynyl, propynyl or cyano; R⁵ is selected from a group consisting of an unsubstituted (C₁-C₈)alkyl or unsubstituted aryl; R⁶ is unsubstituted (C₁-C₈)alkyl. The invention also relates to methods of producing the compound of formula (I) (versions). The compounds of formula (I) are intended for preparing a pharmaceutical composition or a medicinal agent for treating a disease associated with a poly (ADP-ribose) polymerase (PARP) inhibitor, or for treating cancer, which contains an effective dose of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

EFFECT: benzamide derivatives intended for producing a medicinal agent for treating a disease associated with a poly (ADP-ribose) polymerase (PARP) inhibitor, or cancer.

20 cl, 2 tbl, 37 ex