TRYPTOLIDE DERIVATIVE, METHOD FOR ITS PREPARATION AND APPLICATION Russian patent published in 2021 - IPC C07J73/00 C07D493/22 A61K31/58 A61P35/00 A61P37/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound represented by the formula I, or its pharmacologically acceptable salt, where R₁ is a substituted or unsubstituted group selected from a group consisting of a phenyl and a 5-membered heteroaryl containing 1 heteroatom selected from O; Y is O; R₂ is -C (=O)R₄, where R₄ is a substituted or unsubstituted group selected from a group consisting of cyclohexyl, phenyl and a 5-membered heteroaryl containing 1 heteroatom selected from O; is a double bond or a single bond, and when it is a double bond, R₃ represents O, when it is a single bond, R₃ represents OR₅ or F, while R₅ represents H, Boc, CH₂SCH₃, -CH₂OP(=O)(OH)₂ or -CH₂OP(=O)(OBn)₂; each X represents H; each of the above terms “substituted” independently means that one hydrogen atom in the group is replaced by a substituent selected from a group consisting of a halogenated C1-C8 alkyl and an unsubstituted C1-C8 alkoxy. The invention also relates to methods for obtaining these compounds and to a pharmaceutical composition that has an immunosuppressive and antitumor effect, based on them.

EFFECT: obtaining new compounds and a pharmaceutical composition based on them, which can be used in medicine for the treatment of tumor diseases.

I

9 cl, 2 dwg, 4 tbl, 13 ex