URACIL DERIVATIVE AGENT FOR THERAPY OF ALZHEIMER DISEASE Russian patent published in 2015 - IPC C07D239/54 A61K31/513 A61P25/28 

Abstract RU 2565756 C1

FIELD: medicine.

SUBSTANCE: invention refers to the new uracil derivative 1,3-bis[5-(orto-nitrobenzyl-ethylamino)pentyl-1]-6-methyluracil described by structural formula presented below. The compound is applicable in therapy of Alzheimer disease. Presented are anticholinesterase activity indices of the compound, its general toxic action and findings obtained in a scopolamine and genetic model in the therapy of symptoms of Alzheimer disease.

EFFECT: higher clinical effectiveness ensured by the above agent.

2 cl, 5 tbl, 6 ex

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RU 2 565 756 C1

Authors

Petrov Konstantin Aleksandrovich

Semenov Vjacheslav Ehngel'Sovich

Reznik Vladimir Savich

Nikol'Skij Evgenij Evgen'Evich

Zobov Vladimir Vasil'Evich

Kharlamova Aleksandra Dmitrievna

Zueva Irina Vladimirovna

Sajfina Lilija Fuadovna

Minnekhanova Oksana Aleksandrovna

Mukhamed'Jarov Marat Aleksandrovich

Petukhova Elena Olegovna

Dates

2015-10-20Published

2014-12-22Filed