FIELD: medicine.
SUBSTANCE: discovering process is shown in pentylenetetrazole kindling model involving male C57B1/6 mice. Action of citicoline is determined after administered in a dose of 500 mg/kg one hour before administration of pentylenetetrazole. The administration is conducted in the different regimens in different groups of animals, in particular: daily during 24 days, once on the 14th day of kindling or during 14 days of kindling.
EFFECT: possibility to discover a spectrum and degree of manifestation of anticonvulsant action of the preparation.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DETECTING ANTICONVULSANT ACTION OF SODIUM CITICOLINE AND VALPROATE WHEN APPLYING THEM TOGETHER ON MODEL OF ACUTE GENERALIZED CONVULSIONS CAUSED BY PENTYLENETETRAZOLE IN WISTAR MALE RATS | 2015 |
|
RU2600477C1 |
| METHOD OF MODELLING PAROXYSMAL CONVULSIVE DISORDER | 2009 |
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| N-ALKYL-TROPINES AND N-ALKYL-NORTROPINES HAVING h-LYTIC, ANTIPARKINSONIAN, ANTIEPILEPTIC, ANALGESIC AND ANTIDEPRESSANT ACTIVITY | 2014 |
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RU2597616C2 |
| 4-BENZOYLPYRIDINE OXIME DERIVATIVES HAVING ANTICONVULSANT ACTIVITY AS AGENTS FOR TREATMENT OF EPILEPSY AND PAROXYSMAL STATES | 2016 |
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RU2643091C2 |
| 3-BENZYLAMINOMETHYLENEPYRROLIDINE-2,4-DIONE AND ANTICONVULSANT AGENT BASED ON SAID | 1997 |
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| PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING PAROXYSMAL CONDITIONS | 2011 |
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| DIBENZOFURAN OXIME DERIVANTS WITH ANTICONVULSANT AND NEUROPROTECTIVE ACTIVITY | 2018 |
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| ANTI-CONVULSIVE MEDICINE | 2008 |
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