NON-INVASIVE DIAGNOSTIC TECHNIQUE FOR DEGREE OF HEPATIC FIBROSIS Russian patent published in 2015 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: technique involves composing a group of relatively healthy survey individuals (F0), a group of patients histologically diagnosed with a moderate degree of fibrosis (F1-F2) and a group of patients histologically diagnosed with a pronounced degree of fibrosis (F3-F4); average red blood cell suspension velocities and minimum, median and maximum RBC diameters under AC electric field are measured in the group of the relatively healthy survey individuals (F0) and the groups of the patients diagnosed with the moderate degree of fibrosis (F1-F2) and with the pronounced degree of fibrosis (F3-F4). The measured data are used to derive electrical and viscoelastic RBC parameters; the electrical and viscoelastic RBC parameters of the group of the relatively healthy survey individuals (F0) are compared to those in the group of the patients with the moderate degree of fibrosis (F1-F2) and the group of the patients with the pronounced degree of fibrosis (F3-F4). The obtained results provide a basis to form a data array to diagnose a degree of hepatic fibrosis. That is followed by performing similar measurements of RBC samples taken from a patients with an uncertain degree of fibrosis and determining the electrical and viscoelastic RBC parameters to be compared to the respective values determined for the group of the relatively healthy survey individuals (F0), the group of the patients with the moderate degree of fibrosis (F1-F2) and the group of the patients with the pronounced degree of fibrosis (F3-F4), and if 60% or more of the parameters occur to differ from those in the group of the relatively healthy survey individuals (F0) and fall within the range specific for the group of the patients with the moderate degree of fibrosis (F1-F2) or the pronounced degree of fibrosis (F3-F4), the degree of hepatic fibrosis is determined for the specific patient.

EFFECT: more accurate early determination of the degree of hepatic fibrosis notwithstanding the origin of the disease.

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