FIELD: medicine.
SUBSTANCE: invention is a method for diagnostics of severe hepatic fibrosis in patients with chronic hepatitis C (HCV) of a natural course with genotype 1, characterized by activity of cytochemical enzymes lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH) and nicotinamide adenine dinucleotide-diaphorase (NAD-diaphorase) determination in peripheral blood neutrophils and monocytes, and with a decrease in their activity in neutrophils and monocytes by more than three times compared to normal, severe liver fibrosis is diagnosed.
EFFECT: method allows to detect liver fibrosis in chronic hepatitis C in patients who have not received treatment, with a possibility of timely initiation of antiviral therapy.
6 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTING THE COURSE OF CHRONIC GENOTYPE 1 HEPATITIS C IN UNTREATED PATIENTS WITH HIGH VIRAL LOAD | 2017 |
|
RU2657586C1 |
| DIAGNOSTIC TECHNIQUE FOR HEPATIC CIRRHOSIS (STAGE F4) IN THE OUTCOME OF CHRONIC VIRAL HEPATITIS C | 2019 |
|
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| METHOD FOR DIAGNOSING HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C | 2019 |
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|
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| METHOD FOR DETERMINING AVERAGE RATE OF FORMATION OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS C | 2020 |
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| METHOD OF DETERMINING THE AVERAGE RATE OF LIVER FIBROSIS FORMATION IN PATIENTS WITH CHRONIC HEPATITIS B+C | 2022 |
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| TECHNIQUE FOR DIAGNOSTICS OF HEPATIC FIBROSIS STAGES IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C | 2015 |
|
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RU2601113C1 |
