FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of formula I, where A and R1-R4 are determined in formula of invention, or their pharmaceutically acceptable salts. Invention also relates to pharmaceutical composition containing them and application of claimed compounds.
EFFECT: compounds of formula 
are modulators of FXR activity.
14 cl, 20 ex
| Title |
Year |
Author |
Number |
| CARBOXYL- OR HYDROXYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES |
2008 |
- Benson Gregori Martin
- Blajkher Konrad
- Greter Uve
- Kun Bernd
- Martin Rajner Eh.
- Planshe Zhan-Mark
- Rikhter Khans
- Tajlor Sven
- Jan Min'Min'
|
RU2493153C2 |
| SYNTHESIS AND USE OF TETRAHYDROPYROLLO[3,2-c]PYRIDIN-4-ONE DERIVATIVES TO TREAT OBESITY, PSYCHIATRIC AND NEUROLOGICAL DISORDERS |
2006 |
|
RU2415856C2 |
| CONDENSED HETEROCYCLIC COMPOUNDS AND SQUALENE-SYNTHETASE INHIBITORS |
1994 |
- Khidefumi Jukimasa
- Rjuiti Tozava
- Jasuo Sugijama
- Masakuni Kori
|
RU2129547C1 |
| BICYCLIC PYRIDINE DERIVATIVES USEFUL AS FATTY ACID BINDING PROTEIN (FABP) 4 AND / OR 5 INHIBITOR |
2013 |
- Byuttelmann Bernd
- Konte Aureliya
- Kyune Kholger
- Kun Bernd
- Najdkhart Verner
- Obst Zander Ulrike
- Rikhter Khans
|
RU2648247C2 |
| DERIVATIVES OF 4,1-BENZOXAZEPINE, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF ACTIVITY OF SQUALENE SYNTHETASE IN MAMMALS, METHOD OF INHIBITION OF FUNGI GROWTH IN MAMMALS |
1993 |
- Khidefumi Jukimasa
- Rjuiti Tozava
- Masakuni Kori
- Kazuaki Kitano
|
RU2145603C1 |
| DERIVATIVES OF TETRAHYDROCARBAZOLES, METHOD OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
2005 |
- Demlov Genrietta
- Kun Bernd
- Maschjardri Rafaehllo
- Pandaj Nerendra
- Ratni Nasane
- Rajt Matt'Ju Blejk
|
RU2382770C2 |
| DERIVATIVES OF 4,1-BENZOXAZEPINE |
1993 |
- Jukimasa Khidefumi
- Tozava Rjuiti
- Kori Masakuni
- Kitano Kazuaki
|
RU2170732C2 |
| ANTIHYPERTRIGLYCERIDEMIC COMPOSITION (VARIANTS), METHOD OF ITS PREPARING, METHOD OF TREATMENT OR PROPHYLAXIS OF HYPERTRIGLYCERIDEMIA |
1995 |
- Jasuo Sugijama
- Khidefumi Jukimasa
|
RU2166320C2 |
| DERIVATIVES OF 1,3-SUBSTITUTED CYCLOALKENE AND CYCLOALKANE AS A MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS OR THEIR HYDRATES, OR SALTS |
1992 |
- Bredlej Villiam Kehpres
- Dennis Majkl Dauning
- Khuan Karlos Dzhejn
- Stifen Dzhozef Dzhonson
- Villiam Dzhon Iii Smit
- Lourens Dejvid Vajs
- Dzhonatan Rajt
- Dejvid Dzhjurgen Vjustro
|
RU2116297C1 |
| AMINO ACID DERIVATIVES, THEIR PHARMACEUTICALLY ACCEPTABLE SALT AND A METHOD OF THEIR SYNTHESIS |
1991 |
- Kejdzi Khemmi[Jp]
- Masakhiro Neja[Jp]
- Khirosi Marusava[Jp]
- Sin'Ja Vatanabe[Jp]
- Masasi Khasimoto[Jp]
|
RU2057124C1 |
