SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF THEIR APPLICATION Russian patent published in 2015 - IPC C07D401/12 A61K31/4709 A61K45/06 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to novel substituted quinolines of general formula (I), where R¹ stands for hydroxyC_2-6 alkoxy and R² is H, C_1-10alkoxy or hydroxyC_1-10alkoxy; R³ is H or F, R⁴ is H, F, Cl, Br, I or CN; and X is CH or N, or to their stereoisomers, tautomers, or pharmaceutically acceptable salts. Invention also claims pharmaceutical compositions, which include such compounds and methods of applying compounds and compositions in treatment of hyper-proliferative disorders in mammals, especially humans.

EFFECT: claimed compounds inhibit activity of protein- and tyrosinkinase and cell activity, such as proliferation, differentiation, apoptosis, migration and invasion.

15 cl, 3 dwg, 2 tbl, 18 ex