FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to a heterocyclic compound of formula (I), wherein W1 is N or CRC; W2 and W3 are CRC; Z is CN or 
; X is H, (C1-C6)alkyl, wherein (C1-C6)alkyl is optionally substituted with 1 substituent independently selected from ORa; Y is (C3-C6)cycloalkyl or (C6-C10)aryl, where each (C6-C10)aryl is substituted with 2 substituents selected from F; R1 is Cl or ORa; each Ra independently is H or (C1-C6)alkyl; and each Rc is independently H. Also, the invention relates to a pharmaceutical composition based on a compound of formula 
.
EFFECT: technical result is obtaining novel heterocyclic compounds which modulate the activity of tyrosine kinase, which is phosphatidylinositol 3-kinase (PI3K) and MPM (mTOR) and are useful in the treatment of proliferative diseases.
8 cl, 8 tbl, 15 ex
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