6-ARYL-4-MORPHOLINE-1-YL PYRIDONES SUITABLE FOR TREATMENT OF CANCER OR DIABETES Russian patent published in 2021 - IPC C07D413/04 C07D413/14 A61K31/5377 A61P35/00 A61P3/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of the formula (I) and to its pharmaceutically acceptable salts, tautomers and stereoisomers, where R¹ is phenyl or heteroaryl, which is mono- or bicyclic 5-10-element aroma group including one or two heteroatoms independently selected from nitrogen, oxygen or sulfur, wherein the specified phenyl or heteroaryl are optionally substituted with one or two of R⁵, R⁶, R⁷ and R⁸; R², R³ and R⁴ are independently selected from hydrogen and C₁-C₃alkyl; R⁵, R⁶, R⁷ and R⁸ are independently selected from halogen, C₁-C₆alkyl, C₁-C₆haloalkyl, -NHSO₂R⁹, phenyl and 5-6-element monocyclic heteroaryl including one or two nitrogen atoms; R⁹ is C₁-C₃alkyl. The invention also relates to a pharmaceutical composition for inhibiting Vps34 based on the specified compounds of the formula (I).

EFFECT: new compound and the pharmaceutical composition based on it are obtained, which can be used in medicine for the treatment and prevention of such diseases mediated by Vps34 inhibition.

20 cl, 2 tbl, 19 ex