CO-CRYSTALS OF TRANSMEMBRANE CONDUCTION REGULATOR MODULATORS IN CYSTIC FIBROSIS Russian patent published in 2021 - IPC C07D215/56 A61K31/4418 A61P11/00 

Abstract RU 2749213 C2

FIELD: crystal chemistry.

SUBSTANCE: invention relates to co-crystals containing N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), with Compound 1 being represented by the following structural formula:

and only one triglyceride, with the triglyceride being selected from glyceryltrioleate, glyceryltrioctanoate and glyceryltrilinoleate, as well as to the methods for their obtaining and methods for treating cystic fibrosis using them.

EFFECT: treatment of cystic fibrosis with their help.

11 cl, 37 dwg

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RU 2 749 213 C2

Authors

Strohmeier, Mark

Caesar, Jr., John P.

Connelly, Patrick Raymond

Fawaz, Majed

Luss-Lusis, Eduard

Mcclain, Brian R.

Medek, Ales

Miao, Hai

Nti-Addae, Kwame Wiredu

Yin, Ping

Zhang, Yuegang

Dates

2021-06-07Published

2015-10-07Filed