FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to dermatology and can be used for the local treatment of inflammation. A pharmaceutical composition in the form of a water-in-oil-in-water emulsion or a water-in-oil emulsion with a disperse, internal, continuous water phase for local application contains: a lipophilic emulsifier, a thickening agent, saturated hydrocarbon, an inorganic and/or organic additive and antisense oligonucleotide, representing DNAzyme, with the dispersive, internal, continuous water phase containing the said antisense oligonucleotides.
EFFECT: invention makes it possible to increase the stability of oligonucleotides in the composition, protect them from fermentative cleavage, and improve absorption.
9 cl, 4 dwg, 2 ex
