FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Invention describes modified oligonucleotides with length from 15 to 30 nucleotides, containing at least one modification, wherein said at least one modification is selected from: at least one modified sugar fragment; at least one modified internucleotide linkage; at least one modified nucleotide; and their combinations. Wherein said oligonucleotides are specifically hybridized with natural antisense CSF3 gene polynucleotide and have sequence at least by 80 % identical to sequence, back complementary section within nucleotides from 1 to 742 of SEQ ID NO: 2, or have sequence at least by 80 % identical to section of sequence SEQ ID NO: 1. Invention also relates to use of such antisense oligonucleotides for treating diseases and disorders associated with expression of CSF3.
EFFECT: invention extends range of products for treating diseases and disorders associated with expression of CSF3.
30 cl, 1 dwg, 1 tbl, 2 ex
